| Date | Division | Match | String | Opponent | Result |
| 23/09/2021 | Division 5 Central South | New Mills Leisure 2 v Crewe Vagrants 4 | 2 | Howard Lindley | Won 3-1 |
| 30/09/2021 | Division 5 Central South | Crewe Vagrants 4 v Knutsford Sports 5 | 2 | Dave Gordon | Won 3-0 |
| 07/10/2021 | Division 5 Central South | Moss Side 2 v Crewe Vagrants 4 | 2 | Phil Gray | Lost 1-3 |
| 14/10/2021 | Division 5 Central South | Crewe Vagrants 4 v Alderley Edge 8 | 1 | Ben Hamilton-Ryan | Lost 0-3 |
| 21/10/2021 | Division 3 South West | Cheshire Officers 2 v Crewe Vagrants 2 | 5 | Nolan Franklin | Lost 0-3 |
| 28/10/2021 | Division 5 Central South | Marple 4 v Crewe Vagrants 4 | 2 | Andy Brown | Won 3-0 |
| 04/11/2021 | Division 5 Central South | Crewe Vagrants 4 v Macclesfield 3 | 1 | Stephen Ince | Won 3-1 |
| 11/11/2021 | Division 5 Central South | Bollington 5 v Crewe Vagrants 4 | 1 | Sam White | Won 3-0 |
| 18/11/2021 | Division 5 Central South | Crewe Vagrants 4 v Brooklands 4 | 1 | Peter Marsden | Won 3-0 |
| 25/11/2021 | Division 5 Central South | Lymm 2 v Crewe Vagrants 4 | 1 | Ross Pinkerton | Won 3-1 |
| 02/12/2021 | Division 5 Central South | Crewe Vagrants 4 v The Northern 9 | 1 | Alby Stevens | Won 3-0 |
| 09/12/2021 | Division 3 South West | Holywell Leisure SC 1 v Crewe Vagrants 2 | 4 | Jason Shill | Lost 0-3 |
| 27/01/2022 | Division 5 Central South | Crewe Vagrants 4 v Macclesfield 2 | 1 | Ian Hill | Won 3-1 |
| 03/02/2022 | Division 5 Central South | Crewe Vagrants 4 v New Mills Leisure 2 | 1 | Rick Aldred | Won 3-0 |
| 10/02/2022 | Division 5 Central South | Knutsford Sports 5 v Crewe Vagrants 4 | 1 | Mike Sharman | Won 3-0 |
| 17/02/2022 | Division 5 Central South | Crewe Vagrants 4 v Moss Side 2 | 1 | Raphael Thuret | Won 3-1 |
| 24/02/2022 | Division 5 Central South | Alderley Edge 8 v Crewe Vagrants 4 | 1 | Rob Allman | Won 3-2 |
| 10/03/2022 | Division 5 Central South | Crewe Vagrants 4 v Bowdon 6 | 1 | Henrietta Bellamy | Won 3-0 |
| 17/03/2022 | Division 5 Central South | Crewe Vagrants 4 v Marple 4 | 2 | Russell Wickens | Lost 1-3 |
| 31/03/2022 | Division 5 Central South | Crewe Vagrants 4 v Bollington 5 | 1 | Sam White | Won 3-0 |
| 07/04/2022 | Division 5 Central South | Brooklands 4 v Crewe Vagrants 4 | 2 | Oliver Pike | Won 3-1 |
| 14/04/2022 | Division 3 South West | Crewe Vagrants 2 v Heswall 3 | 4 | Paul Grannon | Lost 1-3 |
| 21/04/2022 | Division 3 South West | Cheshire Officers 1 v Crewe Vagrants 2 | 5 | David Jack | Lost 0-3 |
| 28/04/2022 | Division 5 Central South | Crewe Vagrants 4 v Grove Park 6 | 2 | Heath Donnelly | Won 3-0 |
| 05/05/2022 | Division 5 Central South | Macclesfield 2 v Crewe Vagrants 4 | 2 | Ian Hill | Won 3-0 |
