| Date | Division | Match | String | Opponent | Result |
| 23/09/2021 | Division 3 South West | Tattenhall 1 v Crewe Vagrants 2 | 2 | Jonny Jones | Lost 0-3 |
| 30/09/2021 | Division 3 South West | Crewe Vagrants 2 v Wrexham Brymbo 3 | 2 | Mark Davies | Won 3-0 |
| 25/11/2021 | Division 3 South West | Heswall 3 v Crewe Vagrants 2 | 2 | Craig Beecham | Lost 0-3 |
| 02/12/2021 | Division 3 South West | Crewe Vagrants 2 v Cheshire Officers 1 | 3 | David Jack | Won 3-0 |
| 27/01/2022 | Division 3 South West | Crewe Vagrants 2 v Winsford 1 | 2 | Rueben Mather | Lost 1-3 |
| 03/02/2022 | Division 3 South West | Crewe Vagrants 2 v Tattenhall 1 | 3 | Steve Daborn | Lost 2-3 |
| 10/02/2022 | Division 3 South West | Wrexham Brymbo 3 v Crewe Vagrants 2 | 4 | Alistair Blundall | Won 3-0 |
| 10/03/2022 | Division 3 South West | Crewe Vagrants 2 v Cheshire Officers 2 | 2 | Gareth Burroughes | Won 3-1 |
| 17/03/2022 | Division 3 South West | Crewe Vagrants 2 v Neston 2 | 2 | (walkover) | Won 3-0 |
| 24/03/2022 | Division 3 South West | Chester Rugby 2 v Crewe Vagrants 2 | 2 | Gareth Roberts | Won 3-0 |
| 21/04/2022 | Division 3 South West | Cheshire Officers 1 v Crewe Vagrants 2 | 2 | Charlie Carus | Lost 0-3 |
| 28/04/2022 | Division 3 South West | Crewe Vagrants 2 v Holywell Leisure SC 1 | 3 | Alex Day | Won 3-2 |
| 05/05/2022 | Division 3 South West | Winsford 1 v Crewe Vagrants 2 | 3 | John Pratt | Won 3-1 |
