| Date | Division | Match | String | Opponent | Result |
| 23/09/2021 | Division 4 North West | Southport & Birkdale 3 v Woolston 2 | 4 | Simon Matthews | Lost 0-3 |
| 30/09/2021 | Division 4 North West | Warrington 6 v Southport & Birkdale 3 | 5 | Emily Page | Won 3-0 |
| 07/10/2021 | Division 4 North West | Southport & Birkdale 3 v Northern Crosby 6 | 3 | John Daniel Jaques | Won 3-0 |
| 14/10/2021 | Division 4 North West | Wigan Squash 5 v Southport & Birkdale 3 | 5 | Natan Farmas | Won 3-0 |
| 21/10/2021 | Division 4 North West | Southport & Birkdale 3 v Liverpool CC 6 | 4 | Robert Macfarlane | Won 3-1 |
| 28/10/2021 | Division 4 North West | Capitol Squash 3 v Southport & Birkdale 3 | 4 | Les Farrell | Lost 0-3 |
| 11/11/2021 | Division 4 North West | Southport & Birkdale 3 v Warrington 5 | 4 | Philip Voas | Lost 1-3 |
| 18/11/2021 | Division 4 North West | Northern Crosby 5 v Southport & Birkdale 3 | 3 | Liam Crosbie | Won 3-0 |
| 02/12/2021 | Division 4 North West | Wigan Squash 6 v Southport & Birkdale 3 | 4 | Ben Schofield | Lost 0-3 |
| 09/12/2021 | Division 4 North West | Southport & Birkdale 3 v Liverpool CC 7 | 4 | (walkover) | Won 3-0 |
| 27/01/2022 | Division 4 North West | Xaverian 4 v Southport & Birkdale 3 | 4 | Frank McCoy | Won 3-0 |
| 03/02/2022 | Division 4 North West | Woolston 2 v Southport & Birkdale 3 | 4 | Spencer Pritchard | Lost 0-3 |
| 10/02/2022 | Division 4 North West | Southport & Birkdale 3 v Warrington 6 | 2 | Paul Harry | Lost 1-3 |
| 17/02/2022 | Division 4 North West | Northern Crosby 6 v Southport & Birkdale 3 | 4 | Reece Manion | Won 3-0 |
| 24/02/2022 | Division 4 North West | Southport & Birkdale 3 v Wigan Squash 5 | 4 | Ali Swift | Won 3-2 |
| 10/03/2022 | Division 4 North West | Liverpool CC 6 v Southport & Birkdale 3 | 4 | (walkover) | Won 3-0 |
| 17/03/2022 | Division 4 North West | Southport & Birkdale 3 v Capitol Squash 3 | 3 | Craig Wood | Lost 0-3 |
| 31/03/2022 | Division 3 North West | Warrington 4 v Southport & Birkdale 2 | 5 | Joseph Kelly | Lost 0-3 |
| 07/04/2022 | Division 3 North West | Southport & Birkdale 2 v Northern Crosby 4 | 4 | Glen Williams | Won 3-1 |
| 21/04/2022 | Division 3 North West | Southport & Birkdale 2 v Northern Crosby 2 | 3 | Carl Joynson | Lost 1-3 |
| 05/05/2022 | Division 3 North West | Southport & Birkdale 2 v Capitol Squash 2 | 5 | Jim Carroll | Won 3-1 |
