| Date | Division | Match | String | Opponent | Result |
| 23/09/2021 | Division 2 East | City of Manchester 1 v Prestbury 1 | 4 | Mike Lomas | Lost 0-3 |
| 14/10/2021 | Division 3 North East | Fairways Lodge 1 v City of Manchester 2 | 1 | Daniel Blan | Lost 2-3 |
| 28/10/2021 | Division 2 East | City of Manchester 1 v Monton 1 | 5 | Ian Nuttall | Won 3-2 |
| 04/11/2021 | Division 3 North East | City of Manchester 2 v Monton 2 | 1 | Phil Lindoe | Lost 2-3 |
| 18/11/2021 | Division 3 North East | City of Manchester 2 v Markland Hill 1 | 1 | Matthew Muller | Lost 0-3 |
| 09/12/2021 | Division 3 North East | Village Hotel Bury 1 v City of Manchester 2 | 1 | Lloyd Palmer | Lost 0-3 |
| 27/01/2022 | Division 3 North East | City of Manchester 2 v Cheetham Hill 2 | 3 | Bryn Turk | Won 3-1 |
| 10/02/2022 | Division 3 North East | Whitefield Squash 1 v City of Manchester 2 | 4 | Nick Blocksidge | Lost 0-3 |
| 17/02/2022 | Division 3 North East | City of Manchester 2 v Crow Wood 1 | 3 | Nick Uttley | Won 3-1 |
| 24/02/2022 | Division 3 North East | City of Manchester 2 v Fairways Lodge 1 | 4 | Mark McKee | Won 3-0 |
| 10/03/2022 | Division 2 East | City of Manchester 1 v The Northern 2 | 5 | Andrew Laing | Lost 0-3 |
| 24/03/2022 | Division 3 North East | Monton 2 v City of Manchester 2 | 1 | Phil Lindoe | Won 3-0 |
| 07/04/2022 | Division 2 East | City of Manchester 1 v Alderley Edge 3 | 5 | David Leonard | Won 3-0 |
| 14/04/2022 | Division 2 East | Bowdon 2 v City of Manchester 1 | 5 | (walkover) | Won 3-0 |
| 21/04/2022 | Division 2 East | City of Manchester 1 v Grove Park 2 | 5 | Charlie Beauchamp | Won 3-0 |
| 28/04/2022 | Division 2 East | The Northern 3 v City of Manchester 1 | 4 | Elliot Hobbs | Lost 1-3 |
