| Date | Division | Match | String | Opponent | Result |
| 23/09/2021 | Division 2 East | Crewe Vagrants 1 v Hyde 1 | 3 | Alex Bowden | Lost 0-3 |
| 30/09/2021 | Division 2 East | Prestbury 1 v Crewe Vagrants 1 | 4 | Mike Lomas | Won 3-2 |
| 07/10/2021 | Division 2 East | Crewe Vagrants 1 v Alderley Edge 2 | 4 | Mark Weems | Lost 1-3 |
| 04/11/2021 | Division 3 South West | Crewe Vagrants 2 v Chester Rugby 2 | 1 | Richard Taylor | Won 3-0 |
| 25/11/2021 | Division 2 East | Crewe Vagrants 1 v Alderley Edge 3 | 4 | Steve Flanagan | Lost 0-3 |
| 02/12/2021 | Division 3 South West | Crewe Vagrants 2 v Cheshire Officers 1 | 1 | Charlie Carus | Won 3-1 |
| 09/12/2021 | Division 2 East | Crewe Vagrants 1 v Grove Park 2 | 4 | Liam Foster | Lost 0-3 |
| 27/01/2022 | Division 2 East | The Northern 3 v Crewe Vagrants 1 | 5 | Nehal Ramlukan | Won 3-1 |
| 03/02/2022 | Division 3 South West | Crewe Vagrants 2 v Tattenhall 1 | 1 | Tom Hulse | Won 3-1 |
| 10/02/2022 | Division 2 East | Crewe Vagrants 1 v Prestbury 1 | 5 | Graeme English | Won 3-0 |
| 17/03/2022 | Division 2 East | The Northern 2 v Crewe Vagrants 1 | 3 | Josh Morris | Lost 0-3 |
| 24/03/2022 | Division 2 East | Crewe Vagrants 1 v Monton 1 | 5 | Neil McLoughlin | Won 3-0 |
| 31/03/2022 | Division 2 East | Brooklands 1 v Crewe Vagrants 1 | 4 | James Mc Millan | Lost 0-3 |
| 07/04/2022 | Division 2 East | Crewe Vagrants 1 v Marple 1 | 4 | Nick Hague | Lost 2-3 |
| 14/04/2022 | Division 2 East | Alderley Edge 3 v Crewe Vagrants 1 | 4 | Steve Flanagan | Lost 1-3 |
| 21/04/2022 | Division 2 East | Crewe Vagrants 1 v Bowdon 2 | 4 | Tom Jones | Won 3-0 |
| 28/04/2022 | Division 3 South West | Crewe Vagrants 2 v Holywell Leisure SC 1 | 1 | Mike Dykins | Won 3-2 |
| 05/05/2022 | Division 2 East | Crewe Vagrants 1 v The Northern 3 | 5 | Samuel Wadsworth | Won 3-1 |
